Relapse, re-infection and mixed infections in tuberculosis disease.
Identifieur interne : 000310 ( Main/Exploration ); précédent : 000309; suivant : 000311Relapse, re-infection and mixed infections in tuberculosis disease.
Auteurs : Amanda Mcivor [Afrique du Sud] ; Hendrik Koornhof [Afrique du Sud] ; Bavesh Davandra Kana [Afrique du Sud]Source :
- Pathogens and disease [ 2049-632X ] ; 2017.
Descripteurs français
- KwdFr :
- Antituberculeux (pharmacologie), Antituberculeux (usage thérapeutique), Co-infection, Humains, Mycobacterium tuberculosis (), Mycobacterium tuberculosis (génétique), Prévalence, Récidive, Résistance bactérienne aux médicaments, Techniques de typage bactérien, Tuberculose (microbiologie), Tuberculose (traitement médicamenteux), Tuberculose (épidémiologie), Tuberculose (étiologie), Études rétrospectives.
- MESH :
- génétique : Mycobacterium tuberculosis.
- microbiologie : Tuberculose.
- pharmacologie : Antituberculeux.
- traitement médicamenteux : Tuberculose.
- usage thérapeutique : Antituberculeux.
- épidémiologie : Tuberculose.
- étiologie : Tuberculose.
- Co-infection, Humains, Mycobacterium tuberculosis, Prévalence, Récidive, Résistance bactérienne aux médicaments, Techniques de typage bactérien, Études rétrospectives.
English descriptors
- KwdEn :
- Antitubercular Agents (pharmacology), Antitubercular Agents (therapeutic use), Bacterial Typing Techniques, Coinfection, Drug Resistance, Bacterial, Humans, Mycobacterium tuberculosis (classification), Mycobacterium tuberculosis (drug effects), Mycobacterium tuberculosis (genetics), Prevalence, Recurrence, Retrospective Studies, Tuberculosis (drug therapy), Tuberculosis (epidemiology), Tuberculosis (etiology), Tuberculosis (microbiology).
- MESH :
- chemical , pharmacology : Antitubercular Agents.
- chemical , therapeutic use : Antitubercular Agents.
- classification : Mycobacterium tuberculosis.
- drug effects : Mycobacterium tuberculosis.
- drug therapy : Tuberculosis.
- epidemiology : Tuberculosis.
- etiology : Tuberculosis.
- genetics : Mycobacterium tuberculosis.
- microbiology : Tuberculosis.
- Bacterial Typing Techniques, Coinfection, Drug Resistance, Bacterial, Humans, Prevalence, Recurrence, Retrospective Studies.
Abstract
Tuberculosis (TB) disease can be characterized by genotypic and phenotypic complexity in Mycobacterium tuberculosis bacilli within a single patient. This microbiological heterogeneity has become an area of intense study due its perceived importance in drug tolerance, drug resistance and as a surrogate measure of transmission rates. This review presents a descriptive analysis of research describing the prevalence of mixed-strain TB infections in geographically distinct locations. Despite significant variation in disease burden and a rampant human immunodeficiency virus (HIV)-TB co-epidemic, there was no difference in the prevalence range of mixed infections reported in African countries when compared to the rest of the world. The occurrence of recurrent TB was associated with a higher prevalence of mixed-strain infections, but this difference was not reported as statistically significant. These interpretations were limited by differences in the design and overall size of the studies assessed. Factors such as sputum quality, culture media, number of repeated culture steps, molecular typing methods and HIV-infection status can affect the detection of mixed-strain infection. It is recommended that future clinical studies should focus on settings with varying TB burdens, with a common sample processing protocol to gain further insight into these phenomena and develop novel transmission blocking strategies.
DOI: 10.1093/femspd/ftx020
PubMed: 28334088
Affiliations:
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Le document en format XML
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Kana</name><affiliation wicri:level="1"><nlm:affiliation>DST/NRF Centre of Excellence for Biomedical TB Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg 2000, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>DST/NRF Centre of Excellence for Biomedical TB Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg 2000</wicri:regionArea><wicri:noRegion>Johannesburg 2000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pathogens and disease</title><idno type="eISSN">2049-632X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antitubercular Agents (pharmacology)</term><term>Antitubercular Agents 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This microbiological heterogeneity has become an area of intense study due its perceived importance in drug tolerance, drug resistance and as a surrogate measure of transmission rates. This review presents a descriptive analysis of research describing the prevalence of mixed-strain TB infections in geographically distinct locations. Despite significant variation in disease burden and a rampant human immunodeficiency virus (HIV)-TB co-epidemic, there was no difference in the prevalence range of mixed infections reported in African countries when compared to the rest of the world. The occurrence of recurrent TB was associated with a higher prevalence of mixed-strain infections, but this difference was not reported as statistically significant. These interpretations were limited by differences in the design and overall size of the studies assessed. Factors such as sputum quality, culture media, number of repeated culture steps, molecular typing methods and HIV-infection status can affect the detection of mixed-strain infection. It is recommended that future clinical studies should focus on settings with varying TB burdens, with a common sample processing protocol to gain further insight into these phenomena and develop novel transmission blocking strategies.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li></country></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Mcivor, Amanda" sort="Mcivor, Amanda" uniqKey="Mcivor A" first="Amanda" last="Mcivor">Amanda Mcivor</name></noRegion><name sortKey="Kana, Bavesh Davandra" sort="Kana, Bavesh Davandra" uniqKey="Kana B" first="Bavesh Davandra" last="Kana">Bavesh Davandra Kana</name><name sortKey="Koornhof, Hendrik" sort="Koornhof, Hendrik" uniqKey="Koornhof H" first="Hendrik" last="Koornhof">Hendrik Koornhof</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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